Oxygen sensor (Long term > 6month Implantation)
Electrochemistry is a well established, acurate way to measure dissolved oxygen, and there is good evidence that oxygen levels in brain ECF are related to cerebral blood flow. Our Carbon Paste Oxygen sensor overcomes common issues seen with metal electrodes such as lipid and protein fouling of the electrode surface following implantation, which leads to a continuous loss of sensitivity. The measuring surface of our Oxygen sensors consists of a carbon - silicon oil mix which is inert to fouling. It allows for months of sustained, stable oxygen measurements once implanted. This will provide measurements of brain tissue oxygen in any target area.
We also have a Polymer-coated Oxygen Sensor available.
Selectivity:
Due to its abundance and the voltage at which oxygen gets reduced (-650 mV in our system), selectivity is not an issue and the signal from interfering compounds is negligible.
Sensitivity:
Dissolved oxygen can be measured reliably over the full physiological range. The sensitivity of our electrodes is approximately -1.5 nA/µM dissolved oxygen with a detection limit of ~0.1μM. Each sensor is calibrated individually encompassing the physiological concentration of tissue oxygen in brain (50µM). The response time to changes in oxygen concentration is immediate (<1 sec).
Size:
The oxygen sensor consists of a teflon coated silver wire with an external diameter of 225μm. The total electrode length can be customised according to your needs and depending on the depth of the target brain area. A standard length is 3-4cm.
Application:
This oxygen sensor is designed for implantation in the brain by stereotaxic surgery. Based on the principles of constant potential amperometry, at constant potential is delivered to the oxygen sensor by means of a potentiostat. The oxygen sensor: potentiostat connectivity can either occur external to the animal (tethered solution) or internally attached to a fully implantable telemetry potentiostat (telemetry solution).
The oxygen telemetry system developed in collaboration with Telemetry Research, New Zealand, has the advantage of allowing fully freely moving behavioural experiments. The sensor can also be used for standard tethered recordings which are useful for pharmacological profiling and other experiments were extended animal movement is not necessary.
Price:
Euro 250 / electrode. (Reference and auxiliary electrode are required as well, Euro 50 each).
We also have a Polymer-coated Oxygen Sensor available.
Selectivity:
Due to its abundance and the voltage at which oxygen gets reduced (-650 mV in our system), selectivity is not an issue and the signal from interfering compounds is negligible.
Sensitivity:
Dissolved oxygen can be measured reliably over the full physiological range. The sensitivity of our electrodes is approximately -1.5 nA/µM dissolved oxygen with a detection limit of ~0.1μM. Each sensor is calibrated individually encompassing the physiological concentration of tissue oxygen in brain (50µM). The response time to changes in oxygen concentration is immediate (<1 sec).
Size:
The oxygen sensor consists of a teflon coated silver wire with an external diameter of 225μm. The total electrode length can be customised according to your needs and depending on the depth of the target brain area. A standard length is 3-4cm.
Application:
This oxygen sensor is designed for implantation in the brain by stereotaxic surgery. Based on the principles of constant potential amperometry, at constant potential is delivered to the oxygen sensor by means of a potentiostat. The oxygen sensor: potentiostat connectivity can either occur external to the animal (tethered solution) or internally attached to a fully implantable telemetry potentiostat (telemetry solution).
The oxygen telemetry system developed in collaboration with Telemetry Research, New Zealand, has the advantage of allowing fully freely moving behavioural experiments. The sensor can also be used for standard tethered recordings which are useful for pharmacological profiling and other experiments were extended animal movement is not necessary.
Price:
Euro 250 / electrode. (Reference and auxiliary electrode are required as well, Euro 50 each).
| Type | Title | Size | Date |
 PDF | Oxygen Sensor User Guide | 920 kbs | 10th May 2011 |
| PDF | Oxygen Sensor Information Flyer | 539 kbs | 2nd December 2010 |
